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CD144 (cadherin-5, vascular endothelial cadherin, VE-cadherin, 74B antigen, CDH5)
Function:
- cadherin
- may play role in endothelial cell function through control of thecohesion & organization of the intercellular junctions
- associates with alpha-catenin forming a link to the cytoskeleton
Structure: contains 5 cadherin domains
Compartment:
- cell junction, cell membrane
- found at cell-cell boundaries & probably at cell-matrix boundaries
Expression: endothelial tissues & brain
General
cadherin
glycoprotein
phosphoprotein
Properties
SIZE: MW = 88 kD
entity length = 784 aa
COMPARTMENT: plasma membrane
CELL: endothelial cell
MOTIF: signal sequence {1-25}
cadherin domain {48-151}
MOTIF: N-glycosylation site {N61}
N-glycosylation site {N112}
cadherin domain {152-258}
MOTIF: N-glycosylation site {N157}
cadherin domain {259-372}
MOTIF: N-glycosylation site {N362}
cadherin domain {373-477}
MOTIF: N-glycosylation site {N442}
cadherin domain {478-593}
MOTIF: N-glycosylation site {N523}
N-glycosylation site {N535}
transmembrane domain {600-620}
Tyr phosphorylation site {Y685}
serine-rich region {736-753}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 601120
UniProt P33151
PFAM correlations
Entrez Gene 1003
Kegg hsa:1003
References
- UniProt :accession P33151
- Entrez Gene :accession 1003