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cadherin

Function: - Ca+2-dependent cell adhesion proteins - control of adhesion specificities through homophilic binding interactions - thus, cadherins bind to themselves as receptor & ligand - role in sorting of heterogeneous cell types - cadherin/catenin complexes associate with the cytoskeleton & src family of tyrosine kinases

Related

catenin protocadherin (PCDH) protocadherin fat 1; cadherin-related tumor suppressor homolog; protein fat homolog; cadherin family member 7 (FAT1, CDHF7, FAT) protocadherin fat 2; hfat2; multiple epidermal growth factor-like domains protein 1; multiple EGF-like domains protein 1; cadherin family member 8 (FAT2, CDHF8, KIAA0811, MEGF1)

Specific

cadherin-2; neural cadherin; N-cadherin; CDw325; CD325 (CDH2, CDHN, NCAD) cadherin-3; placental cadherin; P-cadherin (CDH3, CDHP) cadherin-4; retinal cadherin; R-cadherin; R-CAD (CDH4) cadherin-5 (CD144, vascular endothelial cadherin, VE-cadherin, 74B antigen, CDH5) cadherin-6 (kidney cadherin, K-cadherin, CDH6) cadherin-7 (CDH7, CDH7L1) cadherin-8 cadherin-9 (CDH9) cadherin-10; T2-cadherin (CDH10) cadherin-11; osteoblast cadherin; OB-cadherin; OSF-4 (CDH11) cadherin-12; brain cadherin; BR-cadherin; neural type cadherin 2; N-cadherin 2 (CDH12) cadherin-13; Truncated cadherin; T-cadherin; T-cad; heart cadherin; H-cadherin; P105 (CDH13, CDHH) cadherin-15; muscle cadherin; M-cadherin; cadherin-14 (CDH15 CDH14 CDH3) cadherin-16; kidney-specific cadherin; Ksp-cadherin (CDH16) cadherin-17; liver-intestine cadherin; LI-cadherin; intestinal peptide-associated transporter HPT-1 (CDH17) cadherin-18; cadherin-14 (CDH18, CDH14) cadherin-19 (CDH19 CDH7L2 UNQ478/PRO941) cadherin-20 (CDH20, CDH7L3) cadherin-22; pituitary & brain cadherin; PB-cadherin (CDH22, C20orf25) cadherin-23; otocadherin (CDH23, KIAA1774, KIAA1812, UNQ1894/PRO4340) cadherin-24 (CDH24, CDH11L, UNQ2834/PRO34009) cadherin-like protein 26; cadherin-like protein VR20 (CDH26) Cadherin-like protein 28 (CDH28, CDHR3) cadherin-like protein UNQ9392/PRO34300 (CDHR4) CD324; E-cadherin; cadherin-1; epithelial cadherin; uvomorulin; CAM 120/80 (CDH1, CDHE, UVO)

General

adhesion receptor Ca+2 binding protein glycoprotein

Properties

COMPARTMENT: plasma membrane MOTIF: focal adhesion site glycosylation site transmembrane domain binding site FOR-BINDING-OF: catenin Ca+2-binding site SITE: C-TERMINAL

References

  1. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991 Mar 22;251(5000):1451-5. Review. PMID: 2006419
  2. Walsh FS et al N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. J Neurochem. 1990 Sep;55(3):805-12. PMID: 2384753