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cachexia
Also see: cachexia-anorexia syndrome.
Clinical manifestations:
1) progressive weight loss
2) lipolysis
3) loss of visceral & skeletal protein mass
Management:
- artificial nutrition does not improve morbidity or mortality [2]
- olanzapine may improve appetite, weight & quality of life in patients with metastatic cancer [3]
- small meals of foods preferred by elderly at the end of life [4]
Specific
anorexia-cachexia syndrome
cachexia-anorexia syndrome
General
unintentional weight loss
References
- Bruera E, Neumann CM.
Management of specific symptom complexes in patients receiving
palliative care.
CMAJ. 1998 Jun 30;158(13):1717-26. Review.
PMID: 9676549 PMCID: PMC1229444 Free PMC article
- Medical Knowledge Self Assessment Program (MKSAP) 19
Board Basics. An Enhancement to MKSAP19.
American College of Physicians, Philadelphia 2022
- Sandhya L et al.
Randomized double-blind placebo-controlled study of olanzapine for chemotherapy-
related anorexia in patients with locally advanced or metastatic gastric,
hepatopancreaticobiliary, and lung cancer.
J Clin Oncol 2023 May 10; 41:2617
PMID: 36977285 Clinical Trial.
https://ascopubs.org/doi/10.1200/JCO.22.01997
- Roeland EJ, Bohlke K, Baracos VE et al
Cancer Cachexia: ASCO Guideline Rapid Recommendation Update.
J Clin Oncol. 2023 Sep 1;41(25):4178-4179.
PMID: 37467399
- Geriatric Review Syllabus, 11th edition (GRS11)
Harper GM, Lyons WL, Potter JF (eds)
American Geriatrics Society, 2022