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carbonic anhydrase-12 (tumor antigen HOM-RCC-3.1.3, CA12)
Function:
- reversible hydration of carbon dioxide
- inhibited by acetazolamide
H2CO3 CO2 + H2O
Cofactor: Zn+2 (putative)
Structure: belongs to the alpha-carbonic anhydrase family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- highly expressed in colon, kidney, prostate, intestine & activated lymphocytes
- moderately expressed in pancreas, ovary & testis
Pathology:
- expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue
General
carbonic anhydrase (dehydratase)
glycoprotein
membrane protein
metalloprotein
Properties
SIZE: entity length = 354 aa
MW = 39 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
N-glycosylation site {N28}
cysteine residue {C50}
MODIFICATION: cysteine residue {C230}
N-glycosylation site {N80}
Zn+2-binding site
SITE: 119-119
Zn+2-binding site
SITE: 121-121
Zn+2-binding site
SITE: 145-145
N-glycosylation site {N162}
cysteine residue {C230}
MODIFICATION: cysteine residue {C50}
transmembrane domain {302-322}
Database Correlations
OMIM 603263
UniProt O43570
Pfam PF00194
Entrez Gene 771
Kegg hsa:771
ENZYME 4.2.1.1
References
UniProt :accession O43570