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C-peptide in serum
Indications:
1) assessement of surreptitious insulin administration
2) assessment of beta-cell function in the presence of exogenous insulin administration
Normal range:
- 0.78-1.89 ng/mL (0.26-0.63 nM)
Clinical significance:
- a strong correlation between secreted insulin levels & C-peptide exists
- molar excess of C-peptide/insulin occurs due to the longer 1/2 life of C-peptide
Increases:
1) insulinoma
2) pancreas or beta-cell transplant
3) pharmaceutical agents
a) chloroquine
b) danazol
c) ethinyl estradiol
d) oral contraceptives
Decreases:
1) diabetes mellitus, type 1
2) factitious hypoglycemia due to surreptitious insulin administration
Method:
- RIA
Specimen:
- serum
- store at -70 C
- stable for 30 days frozen
Related
C-peptide
General
C-peptide in body fluid
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- C-Peptide, Serum or Plasma
Laboratory Test Directory ARUP: 70103
Component-of
insulin-induced C-peptide suppression panel