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c-myc proto-oncogene
oncogene, avian myelocytomatosis virus; There exists an inverse relationship with c-myc expression & cellular differentiation.
Related
c-myc proto-oncogene protein; transcription factor p64 (c-Myc, MYC)
General
myc proto-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: c-myc proto-oncogene protein
LOCUS: human chromosome-8 Q24.1
MOTIF: E2F site
interferon response element
NAME: interferon response element
nuclease-hypersensitive element
SITE: -142
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 190080
MORBIDMAP 190080
References
- Herschman HR
Extracellular signals, transcriptional responses and cellular
specificity
TIBS 14:455 1989
PMID: 2696174
- Mudryj M, Hiebert SW, Nevins JR.
A role for the adenovirus inducible E2F transcription factor
in a proliferation dependent signal transduction pathway.
EMBO J. 1990 Jul;9(7):2179-84.
PMID: 2141565
- OMIM :accession 190080
- Postel EH, Berberich SJ, Flint SJ, Ferrone CA.
Human c-myc transcription factor PuF identified as nm23-H2
nucleoside diphosphate kinase, a candidate suppressor of tumor
metastasis.
Science. 1993 Jul 23;261(5120):478-80.
PMID: 8392752