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transcription factor Maf; maf proto-oncogene protein; v-maf musculoaponeurotic fibrosarcoma oncogene homolog; proto-oncogene protein c-maf (MAF)

Function: - downregulates antioxidant-response element mediated gene expression - upregulates Maf recognition element (MARE) mediated p53 gene expression [2] Structure: - belongs to the bZIP family, Maf subfamily - contains 1 bZIP domain - may contain transcriptional activation domain - may be classified as large Maf Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Pathology: - chromosomal translocation t(14;16)(q32.3;q23) involving MAF with an IgH locus is found in some forms of multiple myeloma - defects in MAF are the cause of a) juvenile-onset pulverulent cataract b) congenital cerulean cataract 4

Related

maf proto-oncogene

General

maf family protein proto oncogene protein

Properties

SIZE: entity length = 403 aa MW = 42 kD COMPARTMENT: cell nucleus MOTIF: alanine-rich region {139-146} MOTIF: alanine residue (SEVERAL) alanine-rich region {169-173} MOTIF: alanine residue (SEVERAL) histidine-rich region {180-187} MOTIF: histidine residue (SEVERAL) histidine-rich region {191-194} MOTIF: histidine residue (SEVERAL) glycine-rich region {211-220} glycine-rich region {225-238} DNA-binding motif SITE: 288-314 leucine zipper SITE: 316-337 FOR-BINDING-VIA: leucine zipper

Database Correlations

OMIM 177075 UniProt O75444 PFAM correlations Entrez Gene 4094

References

  1. UniProt :accession O75444
  2. Dhakshinamoorthy S & Jaiswal AK c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction. Oncogene 21:5301, 2002 PMID: 12149651