Contents

Search

proto-oncogene protein c-Fos; cellular oncogene protein fos; G0/G1 switch regulatory protein 7 (FOS, G0S7)

Function: - nuclear phosphoprotein - heterodimer with JUN - forms a tight but non-covalent complex with JUN, the AP-1 transcription factor - in the AP-1 heterodimer, c-fos & JUN basic regions each seem to interact with symmetrical DNA half sites - regulates development of cells destined to form & maintain the skeleton - role in signal transduction, cell proliferation & differentiation - interacts with DSIPI; interaction inhibits the binding of active AP1 to its target DNA - interacts with MAFB (putative) - basic amino acids flanking Cys-154 probably stablilize the anionic form of Cys; oxidation of Cys-154, presumably to sulfenic (RSOH) or sulfinic (RSO2H) acid or disulfide, may inactivate DNA-binding capacity Structure: - belongs to the bZIP family, Fos subfamily - contains 1 bZIP domain Compartment: nucleus Expression: - C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress & cell injury

Interactions

molecular events

Related

fos proto-oncogene or TIS28

General

fos protein family PEST protein proto oncogene protein

Properties

SIZE: entity length = 380 aa MW = 41 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 139-160 leucine zipper SITE: 165-193 FOR-BINDING-VIA: leucine zipper Thr phosphorylation site {T232} Thr phosphorylation site {T325} Thr phosphorylation site {T331} Ser phosphorylation site {S362} Ser phosphorylation site {S374} MISC-INFO: 1/2life 0.5 HOURS

Database Correlations

OMIM 164810 UniProt P01100 Pfam PF00170 Entrez Gene 2353 Kegg hsa:2353

References

  1. Kouzarides T, Ziff E. The role of the leucine zipper in the fos-jun interaction. Nature. 1988 Dec 15;336(6200):646-51. PMID: 2974122
  2. Dwarki VJ, Montminy M, Verma IM. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J. 1990 Jan;9(1):225-32. PMID: 2136830
  3. Abate C, Patel L, Rauscher FJ 3rd, Curran T. Redox regulation of fos and jun DNA-binding activity in vitro. Science. 1990 Sep 7;249(4973):1157-61. PMID: 2118682
  4. Rogers S et al, Amino acids common to rapidly degraded proteins: The PEST hypothesis Science 234:364 1986 (1/2life) PMID: 2876518
  5. UniProt :accession P01100
  6. NIEHS-SNPs http://egp.gs.washington.edu/data/fos/

Component-of

activating protein 1 (AP1)