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complement C1q-alpha chain (complement C1q subunit A, C1QA)
Function:
- component of complement C1q & thus the complement cascade
- binding site for immunoglobulin binds IgM & IgG subclasses IgG1, IgG2, & IgG3
Structure:
- contains 1 C1q domain
- contains 1 collagen-like domain
- O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups
Compartment: secreted
Pathology: defects in C1QA are a cause of C1q deficiency
General
protein subunit
Properties
SIZE: entity length = 245 aa
MW = 26 kD
MOTIF: signal sequence {1-22}
cysteine residue {C26}
MODIFICATION: cysteine residue {C29 IN B CHAIN}
Collagen-like
NAME: Collagen-like
SITE: 31-109
MOTIF: glycine residue
proline residue
hydroxyproline residue
C1q {110-245}
MOTIF: N-glycosylation site {N146}
binding site
FOR-BINDING-OF: IgG
Database Correlations
OMIM 120550
MORBIDMAP 120550
UniProt P02745
PFAM correlations
Kegg hsa:712
References
- OMIM :accession 120550
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 831
- C1QAbase; Note: C1QA mutation db
http://bioinf.uta.fi/C1QAbase/
- SeattleSNPs
http://pga.gs.washington.edu/data/c1qa/
- UniProt :accession P02745
Component-of
complement C1q