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glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (core 1 beta1,3-galactosyltransferase 1, core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, core 1 beta3-Gal-T, C1GalT1, beta 1,3-galactosyltransferase, core 1 O-glycan T-synthase, B3Gal-T8, C1GALT1)
Function:
- glycosyltransferase
- generates core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), a precursor for many extended O-glycans in glycoproteins
- role in many processes, including angiogenesis, thrombopoiesis & kidney homeostasis development
- glycosylation
- interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Cofactor: Mg+2
Structure:
- belongs to the glycosyltransferase 31 family, Beta3- Gal-T subfamily
- homodimer, disulfide-linked (putative)
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- highly expressed in kidney, heart, placenta & liver
Pathology:
- defects in C1GALT1 may be a cause of susceptibility to IgA nephropathy
General
glycosyltransferase
membrane protein
Properties
SIZE: MW = 42 kD
entity length = 363 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {7-29}
Ser phosphorylation site {S235}
Database Correlations
UniProt Q9NS00
ENZYME 2.4.1.122
References
UniProt :accession Q9NS00