nuclear DNA-binding protein C1D (hC1D, C1D)

Function: - plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA - forms a multi-subunit complex with MPP6 & EXOSC10 & this complex along with MTR4 is required for the 3'-5' end processing of the 5.8S rRNA - can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA - can induce apoptosis in a TP53/p53 dependent manner - may regulate the TRAX/TSN complex formation - potentiates transcriptional repression by NR1D1 & THRB (putative) - phosphorylated by PRKDC Structure: - monomer & homodimer - interacts with NR1D1, THRA, THRB, NCOR1 & NCOR2 (putative) - interacts with EXOSC10 - forms a heterotrimeric complex with EXOSC10 & MPP6 in vitro - homodimeric form interacts with TSNAX following gamma-radiation - interacts with RAC3 - belongs to the C1D family Compartment: - cytoplasm, nucleus, nucleolus - EXOSC10 is required for nucleolar localization Expression: - ubiquitous - expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid & salivary gland - expressed at high levels in the fetal; lung, liver & kidney - expressed at low levels in skeletal muscle, appendix, heart, lung & colon - induced by gamma-radiation

Properties

SIZE: entity length = 141 aa MW = 16 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: silencer element SITE: 1-100 MOTIF: NR1D1 interaction {50-100} NCOR1/NCOR2 interaction {100-141}

Database Correlations

OMIM 606997 UniProt Q13901 Pfam PF07493 Kegg hsa:1043

References

UniProt :accession Q13901