protein C19orf29; renal carcinoma antigen NY-REN-24 (CACTIN)

Function: - may have role in pre-mRNA splicing - identified in the spliceosome C complex Alternative splicing: named isoforms=2 Pathology: - antigen recognized by autologous antibody in patients with renal-cell carcinoma Note: An ORF (C19orf029 OS) has been described in the opposite strand of the C-terminus of this gene

General

phosphoprotein protein subunit tumor (cancer or CA) antigen

Properties

SIZE: MW = 80 kD entity length = 690 aa MOTIF: arginine-rich region {33-39} MOTIF: arginine residue (SEVERAL) alanine-rich region {61-65} MOTIF: alanine residue (SEVERAL) coiled coil {67-117} coiled coil {157-209} Ser phosphorylation site {S421}

References

UniProt :accession Q8WUQ7