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CCAAT/enhancer binding protein (C/EBP, CBF, NF-Y protein)

Function: - DNA-binding protein that recognizes two different motifs: a) CCAAT-box common to many promoters b) enhanced core homology common to many enhancers - may regulate growth arrest in differentiating cells - different C/EBP isoforms form homodimers & heterodimers

Related

CCAAT box

Specific

CCAAT-binding transcription factor-1 subunit A (CBF-A), enhancer factor 1A (ef1-A) or DNA-binding protein B (DBPB) CCAAT/enhancer-binding protein-alpha; C/EBP alpha (CEBPA) CCAAT/enhancer-binding protein-beta; C/EBP beta; nuclear factor NF-IL6; transcription factor 5 (CEBPB, TCF5, PP9092) CCAAT/enhancer-binding protein-delta; C/EBP delta; nuclear factor NF-IL6-beta; NF-IL6-beta (CEBPD) CCAAT/enhancer-binding protein-epsilon; C/EBP epsilon (CEBPE) CCAAT/enhancer-binding protein-gamma; C/EBP gamma (CEBPG)

General

basic leucine zipper (bZIP) family protein oligomerizing protein

Properties

CONFIGURATION: dimer COMPARTMENT: cell nucleus CELL-CYCLE: G0 MOTIF: bZIP domain MOTIF: basic DNA-binding motif leucine zipper FOR-BINDING-VIA: leucine zipper FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: leucine zipper acidic region (2) MOTIF: acidic residue (SEVERAL) leucine zipper FOR-BINDING-VIA: leucine zipper basic helix-loop-helix MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix

References

  1. Landschulz WH, Johnson PF, McKnight SL. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science. 1989 Mar 31;243(4899):1681-8. PMID: 2494700
  2. Dwarki VJ, Montminy M, Verma IM. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J. 1990 Jan;9(1):225-32. PMID: 2136830
  3. Umek et al Science 251:288 1991