peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1, peripheral benzodiazepine receptor-interacting protein, PBR-IP, RIM-binding protein 1, RIM-BP1, BZRAP1, KIAA0612, RBP1)

Function: 1) interacts with RIMS1 & RIMS2 - 2nd SH3 domain mediates binding to a proline-rich motif in RIMS1 & RIMS2 2) interacts with BZRP - SH3 & proline-rich domain mediates interaction with BZRP Structure: - SH3 domain & proline-rich domain required for interaction with BZRP - 2nd SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2 Compartment: - cytoplasm, mitochondria - preferentially localizes to mitochondria in the presence of BZRP Alternative splicing: named isoforms=3 Expression: - predominantly expressed in brain, pituitary gland, thymus in adult - in brain adult, expressed in temporal lobe, putamen > amygdala, caudate nucleus, cerebral cortex, occipital, frontal lobe - high expression level in fetal brain, heart, kidney & thymus

Properties

SIZE: MW = 200 kD entity length = 1857 aa COMPARTMENT: mitochondria cytoplasm MOTIF: src homology 3 [SH3] domain SITE: 653-720 fibronectin type III domain or F3 module {791-868} fibronectin type III domain or F3 module {882-955} fibronectin type III domain or F3 module {972-1066} proline-rich region SITE: 1071-1150 MOTIF: proline residue (SEVERAL) glutamate-rich region {1262-1274} MOTIF: glutamate residue (SEVERAL) glutamate-rich region {1334-1346} MOTIF: glutamate residue (SEVERAL) src homology 3 [SH3] domain SITE: 1625-1693 src homology 3 [SH3] domain SITE: 1764-1831

Database Correlations

UniProt O95153 PFAM correlations

References

UniProt :accession O95153