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pseudocholinesterase (cholinesterase-2, acylcholine acylhydrolase, butyrylcholinesterase, BuChE, BCHE)

Function: - responsible for hydrolysis of several drugs, including paralyzing agents succinylcholine & mivacurium - catalyzes hydrolysis of both acetylcholine & butyrylcholine - no other functions known Expression: - present in most cells except erythrocytes - in the brain, BuChE is produced by glia Pathology: - acetylcholinesterase (AcChE) is predominant over butyrylcholinesterase (BuChE) in normal brain; however, during the course of Alzheimer's disease, the relative proportions of AcChE & BuChE change substantially; BuChE increases, wherease AcChE decreases - associated with amyloid plaques in Alzheimer's disease - mutant alleles of CHE1 are responsible for hypocholinesterasemia resulting in succinylcholine sensitivity; homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in succinylcholine with surgical anesthesia Laboratory: - BCHE gene mutation Note: formerly known as serum cholinesterase

Related

amyloid (senile, neuritic) plaque BCHE gene mutation cholinesterase in serum/plasma pseudocholinesterase deficiency; butyrylcholinesterase deficiency

General

cholinesterase glycoprotein oligomerizing protein secreted protein

Properties

CONFIGURATION: tetramer SIZE: entity length = 574 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-28} N-glycosylation site {N45} N-glycosylation site {N85} cysteine residue {C93} MODIFICATION: cysteine residue {C120} cysteine residue {C120} MODIFICATION: cysteine residue {C93} N-glycosylation site {N134} serine residue {S226} N-glycosylation site {N269} cysteine residue {C280} MODIFICATION: cysteine residue {C291} N-glycosylation site {N284} cysteine residue {C291} MODIFICATION: cysteine residue {C280} glutamate residue {E353} N-glycosylation site {N369} cysteine residue {C428} MODIFICATION: cysteine residue {C547} histidine residue {H466} N-glycosylation site {N483} N-glycosylation site {N509} N-glycosylation site {N514} cysteine residue {C547} MODIFICATION: cysteine residue {C428} cysteine residue {C599} MODIFICATION: cysteine residue {C-INTERCHAIN} SECRETED-BY: neuroglia MISC-INFO: 1/2life 12-14 DAYS

Database Correlations

OMIM 177400 MORBIDMAP 177400 UniProt P06276 Entrez Gene 590 ENZYME 3.1.1.8

References

  1. OMIM :accession 177400
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. Role of cholinergic therapy in treatment of Alzheimer's disease & other dementias, Farlow, M et al, 2001
  4. Giacobini E. Cholinergic function and Alzheimer's disease. Int J Geriatr Psychiatry. Sep;18(Suppl 1):S1-5. 2003 Review. pmid: 12973744