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butalbital; allylbarbital (Profundol, Sandoptal)

50 mg used in combination with analgesics, acetaminophen or aspirin +/- caffeine. Adverse effects: 1) common (> 10%) - dizziness, lightheadedness, drowsiness, "hangover effect", nausea, heartburn, stomach pains, dyspepsia, epigastric discomfort 2) less common (1-10%) - confusion, mental depression, unusual excitement, nervousness, constipation, faint feeling, headache, vomiting, insomnia, nightmares, weakness, tiredness, hemolytic anemia, skin rash, dyspnea, gastrointestinal ulceration, anaphylactic shock 3) uncommon (< 1%) - leukopenia, agranulocytosis, thrombocytopenia megaloblastic anemia, iron deficiency anemia occult bleeding, prolongation of bleeding time exfoliative dermatitis, Stevens-Johnson syndrome hypotension, thrombophlebitis respiratory depression, bronchospasm insomnia, nervousness, hallucinations hepatotoxicity, renal insufficiency 4) other [1] - coma - tolerance - dependence Drug interactions: - barbiturates induce CYP1A2, CYP2C9 & CYP3A4 - may diminish levels of drugs metabolized by CYP1A2, CYP2C9 & CYP3A4 Laboratory: - butalbital in specimen - butalbital in hair - butalbital in gastric fluid - butalbital in meconium - butalbital in saliva - butalbital in serum/plasma/blood - butalbital in blood - butalbital in serum/plasma - butalbital in stool - butalbital in urine - butalbital in vitreous fluid

Interactions

drug interactions drug adverse effects (more general classes)

Related

cytochrome p450 1A2 (cytochrome P3-450, phenacetin deethylase, cytochrome p450-4, CYP1A2) cytochrome P450 2C9; cytochrome P450 BP-1; cytochrome P450 MP-4; S-mephenytoin-4-hydroxylase; limonene 6-monooxygenase; limonene 7-monooxygenase (CYP2C9, CYP2C10) cytochrome P450 3A4 (cytochrome P450 C3, nifedipine oxidase, P450-PCN1, NF-25, CYP3A4)

General

barbiturate sedative/hypnotic (tranquilizer)

Properties

SIZE: MW = 224 G/M MISC-INFO: elimination route KIDNEY 1/2life 35 HOURS

Database Correlations

PUBCHEM correlations

References

  1. Physicians Desk Reference. 51st edition, Medical Economics, 1997
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Component-of

acetaminophen/butalbital (Phrenilin) acetaminophen/butalbital/caffeine (Fioricet, Esgic) acetaminophen/butalbital/caffeine/codeine (Fioricet with Codeine) aspirin/butalbital/caffeine (Fiorinal) aspirin/butalbital/caffeine/codeine (Fiorinal with Codeine)