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F-box/WD repeat-containing protein 1A; F-box & WD repeats protein beta-TrCP; E3RSIkappaB; pIkappaBalpha-E3 receptor subunit (BTRC, BTRCP, FBW1A, FBXW1A)
Function:
- substrate recognition component of a SCF complex
- recognizes & binds to phosphorylated target proteins
- binds phosphorylated beta-catenin & promotes ubiquitin mediated proteolysis
- may be involved in ubiquitination & subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase
- required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB & TNF protein modification
- interacts with phosphorylated ubiquitination substrates SMAD3 & SMAD4
- interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, NFKBIB, NFKBIE, NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1 & FBXO5; the interaction requires phosphorylation of the 2 Ser in the substrates' destruction motif D-S-G-X(2,3,4)-S
- binds UBQLN1
- interacts with CDC34 & UBE2R2
- interacts with HIV-1 Vpu
- interacts with FBXW11
- interacts with CUL4A & DDB1
- part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NKBIA & RELA; RELA interacts directly with NFKBIA
Structure:
- contains 1 F-box domain
- contains 7 WD repeats
Compartment: cytoplasm, nucleus (putative)
Alternative splicing: named isoforms=2
General
F-box & WD-repeat protein
Properties
SIZE: entity length = 605 aa
MW = 69 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: F-box domain {190-228}
WD repeat {301-338}
WD repeat {341-378}
WD repeat {381-418}
WD repeat {424-461}
WD repeat {464-503}
WD repeat {505-541}
WD repeat {553-590}
Database Correlations
OMIM 603482
UniProt Q9Y297
PFAM correlations
Entrez Gene 8945
Kegg hsa:8945
References
- UniProt :accession Q9Y297
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/BTRCID451ch10q24.html
- Matsuzawa SI & Reed JC.
Siah-1, SIP, and Ebi collaborate in a novel pathway for
beta-catenin degradation linked to p53 responses.
Molecular Cell 7:915-26, 2001
PMID: 11389839