butyrophilin-like protein 2; BTL-II (BTNL2)

Function: - negative regulator of T-cell proliferation Structure: - belongs to the immunoglobulin superfamily, BTN/MOG family - contains 3 Ig-like V-type domains (immunoglobulin-like) Compartment: - membrane; single-pass type 2 membrane protein - isoform 2 is present in the nuclear membranes, vesicle membranes & plasma membranes - isoform 3 (form associated with risk for sarcoidosis) - found in cytoplasmic vesicle structures - not membrane bound Alternative splicing: named isoforms=6 Expression: - expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis & thymus - induced by proinflammatory cytokines such as TNF & IL1B Pathology: - genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 - a nucleotide transition affecting a splice donor site results in the use of an alternative splice site & the production of isoform 3 - individuals expressing isoform 3 have a higher risk for sarcoidosis

General

human longevity protein immunoglobulin superfamily protein secreted protein

Properties

SIZE: MW = 50 kD entity length = 455 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-26} immunoglobulin superfamily domain {29-140} MOTIF: cysteine residue {C50} MODIFICATION: cysteine residue {C124} cysteine residue {C124} MODIFICATION: cysteine residue {C50} immunoglobulin superfamily domain {142-234} MOTIF: cysteine residue {C164} MODIFICATION: cysteine residue {C218} N-glycosylation site {N210} cysteine residue {C218} MODIFICATION: cysteine residue {C164} immunoglobulin superfamily domain {236-355} MOTIF: cysteine residue {C267} MODIFICATION: cysteine residue {C341} cysteine residue {C341} MODIFICATION: cysteine residue {C267} N-glycosylation site {N427}

Database Correlations

OMIM correlations MORBIDMAP 606000 UniProt Q9UIR0 PFAM correlations Entrez Gene 56244 Kegg hsa:56244

References

UniProt :accession Q9UIR0