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CD157; ADP-ribosyl cyclase 2; cyclic ADP-ribose hydrolase 2; bone marrow stromal antigen 1 (BST1)
Function:
- synthesizes cyclic ADP-ribose, a second messenger that elicits Ca+2 release from intracellular stores
- may be involved in pre-B-cell growth
NAD+ + H2O ADP-ribose + nicotinamide
Structure:
- homodimer
- belongs to the ADP-ribosyl cyclase family
Compartment: cell membrane; lipid-anchor, GPI-anchor
Expression: widely expressed
Pathology:
- patients with rheumatoid arthritis show enhanced expression of CD157 transcripts in bone marrow stromal cell lines; thus CD157 overexpression may play a role in B-cell abnormalities in rheumatoid arthritis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glypiated protein
hydrolase
Properties
SIZE: entity length = 318 aa
MW = 36 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-28}
cysteine residue {C51}
MODIFICATION: cysteine residue {C67}
N-glycosylation site {N66}
cysteine residue {C67}
MODIFICATION: cysteine residue {C51}
cysteine residue {C83}
MODIFICATION: cysteine residue {C163}
N-glycosylation site {N95}
tryptophan residue {109}
cysteine residue {C144}
MODIFICATION: cysteine residue {C157}
N-glycosylation site {N148}
cysteine residue {C157}
MODIFICATION: cysteine residue {C144}
cysteine residue {C163}
MODIFICATION: cysteine residue {C83}
tryptophan residue {172}
N-glycosylation site {N192}
glutamate residue {210}
cysteine residue {C238}
MODIFICATION: cysteine residue {C259}
cysteine residue {C259}
MODIFICATION: cysteine residue {C238}
cysteine residue {C271}
MODIFICATION: cysteine residue {C280}
cysteine residue {C280}
MODIFICATION: cysteine residue {C271}
glycosyl phosphatidylinositol [GPI] membrane anchor {N293}
Database Correlations
OMIM 600387
UniProt Q10588
Pfam PF02267
Entrez Gene 683
Kegg hsa:683
ENZYME 3.2.2.5
References
UniProt :accession Q10588