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serine/threonine protein kinase BRSK2; brain-specific serine/threonine protein kinase 2; BR serine/threonine protein kinase 2; serine/threonine protein kinase 29; serine/threonine protein kinase SAD-A (BRSK2, C11orf7, PEN11B, SADA, STK29, HUSSY-12)

Function: - serine/threonine protein kinase - role in polarization of neurons - phosphorylates MAPT/TAU & WEE1 following phosphorylation & activation by STK11/LKB1 - regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Ser-579 - also regulates neuron polarization by phosphorylation of WEE1 at Ser-642, down-regulating WEE1 in polarized neurons - activated by phosphorylation on Thr-174 by STK11/LKB1 - phosphorylated on Ser-416 - phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39 - not phosphorylated at Thr-174 by CaMKK2 - in contrast, it is phosphorylated & activated by CaMKK1 - may be inactivated via dephosphorylation of Thr-174 by PP2C - may be phosphorylated at Thr-260 by PKA Cofactor: Mg+2 (putative) Structure: - belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily - contains 1 protein kinase domain - contains 1 UBA domain Alternative splicing: named isoforms=5

General

serine/threonine kinase

Properties

SIZE: entity length = 736 aa MW = 82 kD STATE: active state MOTIF: kinase domain SITE: 19-270 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 25-33 ATP-binding site NAME: ATP-binding site SITE: 48-48 aspartate residue {D141} Thr phosphorylation site {T174} Ser phosphorylation site {S178} Thr phosphorylation site {T260} Ser phosphorylation site {S294} UBA domain {297-339} Ser phosphorylation site {S367} Ser phosphorylation site {S382} Thr phosphorylation site {T389} Ser phosphorylation site {S393} Ser phosphorylation site {S412} Thr phosphorylation site {T422} Ser phosphorylation site {S423} proline-rich region SITE: 424-468 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S427} Ser phosphorylation site {S435} Ser phosphorylation site {S466} Ser phosphorylation site {S489} Thr phosphorylation site {T509}

Database Correlations

OMIM 609236 UniProt Q8IWQ3 Pfam PF00069 Entrez Gene 9024 Kegg hsa:9024 ENZYME correlations

References

  1. UniProt :accession Q8IWQ3
  2. OMIM :accession Q8IWQ3