AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A, B-cell regulator of IgH transcription, Bright, E2F-binding protein 1, ARID3A, DRIL1, DRX, E2FBP1)

Function: 1) binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription 2) binds minor groove of a restricted ATC sequence sufficient for nuclear matrix association - sequence motif is present in matrix-associating regions proximal to the promoter & flanking E mu - activates E mu-driven transcription by binding these sites Structure: - contains 1 ARID domain - contains 1 NAP domain (nucleosome assembly protein domain) Compartment: nucleus Expression: - widely expressed - highest expression in skeletal muscle, thalamus, colon

General

AT-rich interactive domain-containing protein (ARID domain-containing protein, ARID) phosphoprotein

Properties

SIZE: MW = 63 kD entity length = 593 aa COMPARTMENT: cell nucleus MOTIF: alanine-rich region {67-70} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S81} Ser phosphorylation site {S88} glutamate-rich region {89-157} MOTIF: glutamate residue (SEVERAL) NAP {129-157} ARID {238-330} alanine-rich region {424-445} MOTIF: alanine residue (SEVERAL) glycine-rich region {550-579}

Database Correlations

OMIM 603265 UniProt Q99856 Pfam PF01388

References

UniProt :accession Q99856