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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; transcription activator BRG1; ATP-dependent helicase SMARCA4; SNF2-beta; protein BRG-1; mitotic growth & transcription activator; protein brahma homolog 1; BRG1-associated factor 190A; BAF190A (SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4)
Function:
- transcriptional coactivator
- cooperates with nuclear hormone receptors to potentiate transcriptional activation
- component of the CREST-BRG1 complex
- component of the BAF complex
- interacts directly with IKFZ1 in the BAF complex
- component of the BAF53 complex
- component of the npBAF complex & nBAF complex, neural stem/progenitor & post-mitotic chromatin remodeling complexes
- SMARCA4/BAF190A may promote neural stem cell self-renewal/ proliferation by enhancing notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (putative)
- component of the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
- component of the BAF53, which preferentially acetylates histone H4 (and H2A) within nucleosomes
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with NR3C1, PGR, SMARD1, TOPBP1 & ZMIM2/ZIMP7
- interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling
- interacts with PHF10/BAF45A
Structure:
- belongs to the SNF2/RAD54 helicase family
- contains 1 bromo domain
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
- contains 1 HSA domain
Compartment: nucleus
General
phosphoprotein
SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily A
Properties
SIZE: entity length = 1647 aa
MW = 185 kD
COMPARTMENT: cell nucleus
MOTIF: SS18L1/CREST interaction {1-282}
MOTIF: Thr phosphorylation site {T11}
HSA {460-532}
lysine-rich region {578-588}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T609}
Ser phosphorylation site {S610}
Ser phosphorylation site {S613}
Ser phosphorylation site {S655}
Ser phosphorylation site {S657}
Ser phosphorylation site {S660}
Ser phosphorylation site {S662}
glutamate-rich region {663-672}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S695}
Ser phosphorylation site {S699}
Ser phosphorylation site {S721}
helicase
NAME: helicase
SITE: 766-931
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 779-786
DEAD/H box
NAME: DEAD/H box
SITE: 881-884
Helicase C-terminal {1084-1246}
glutamate-rich region {1360-1364}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1382}
Ser phosphorylation site {S1452}
bromodomain {1477-1547}
MOTIF: peptide motif {1539-1540}
Ser phosphorylation site {S1570}
glutamate-rich region {1571-1584}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1575}
Ser phosphorylation site {S1586}
Ser phosphorylation site {S1627}
Ser phosphorylation site {S1631}
Ser phosphorylation site {S1640}
Ser phosphorylation site {S1642}
Ser phosphorylation site {S1644}
Database Correlations
OMIM 603254
UniProt P51532
PFAM correlations
Entrez Gene 6597
Kegg hsa:6597
References
- UniProt :accession P51532
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/SMARCA4ID42333ch19p13.html
Component-of
SWI/SNF-A (BAF) chromatin remodeling complex