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breast cancer 21 mRNA expression analysis
Indications:
- evaluation of invasive breast cancer
- assessment of need for chemotherapy [4]
Contraindications:
- not useful for ductal carcinoma in situ [2]
Clinical significance:
- women with estrogen receptor positive breast cancer with < 4 positive lymph nodes & low risk scores on the breast cancer 21 mRNA expression analysis have a favorable prognosis with anti-estrogen therapy alone & do not benefit from chemotherapy [2]
Related
breast cancer
Specific
Oncotype DX for breast cancer
General
mRNA expression analysis
References
- CPT :accession 81519
- Medical Knowledge Self Assessment Program (MKSAP) 18, 19.
American College of Physicians, Philadelphia 2018, 2021
- ARUP Consult: Breast Cancer Biomarkers
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/breast-cancer
- Kalinsky K, Barlow WE, Gralow JR et al.
21-gene assay to inform chemotherapy benefit in node-positive breast cancer.
N Engl J Med 2021 Dec 16; 385:2336
PMID: 34914339
https://www.nejm.org/doi/10.1056/NEJMoa2108873