bromodomain-containing protein 8 (p120, skeletal muscle abundant protein, thyroid hormone receptor coactivating protein 120kD, TrCP120, BRD8, SMAP)

Function: - may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors - isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 & THRB/ERBA2 - at least isoform 1 & isoform 2 are components of the NuA4 histone acetyltransferase (HAT complex) - BRD8 isoform 2 interacts with RXRA/NR2B1 & THRB/ERBA2 - phosphorylated on Thr-264, Ser-268 & Ser-284 - phosphorylated on Thr-124, Ser-128 & Ser-144 - phosphorylated on Thr-264, Ser-268 & Ser-284 Structure: contains 2 bromo domains Compartment: nucleus Expression: - expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta & skeletal muscle Note: uncertain whether Met-1 or Met-32 is the initiator

Properties

SIZE: entity length = 1235 aa MW = 135 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {97-171} Ser phosphorylation site {S637} Ser phosphorylation site {S641} bromodomain {724-794} bromodomain {1120-1190} MOTIF: Thr phosphorylation site {T1151} Ser phosphorylation site {S1152}

Database Correlations

OMIM 602848 UniProt Q9H0E9 Pfam PF00439

References

UniProt :accession Q9H0E9