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BRCC holoenzyme complex
Function:
- has Ubc5-dependent ubiquitin E3 ligase activity ubiquitinates C terminus of p53 in vitro
- association with p53 increases after DNA damage
- enhances cellular survival following DNA damage
- truncation of BRCA1 prevented direct association with brcc36
Structure:
subunits:
- BRCA1, BRCA2, BARD1, BRCC3, BRE, RAD51
General
molecular complex
Properties
SUBUNITS: BRCA1 protein
COMPARTMENT: cell nucleus
MOTIF: Zn finger C4-type
SITE: 24-64
EFFECTOR-BOUND: Zn+2
phosphorylation site
BRCA1 C-terminal (BRCT) motif
BRCA2 protein
MOTIF: PALB2 interaction {1-40}
Ser phosphorylation site {S683}
Ser phosphorylation site {S755}
BRCA2 {1002-1036}
BRCA2 {1212-1246}
BRCA2 {1421-1455}
BRCA2 {1517-1551}
BRCA2 {1664-1698}
BRCA2 {1837-1871}
BRCA2 {1971-2005}
BRCA2 {2051-2085}
FANCD2 interaction {2350-2545}
DNA repair protein Rad51 homolog
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
BRCC36-PROTEIN
BARD1 protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: BRCA1 interaction {26-119}
MOTIF: RING-finger {50-87}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
serine-rich region {400-403}
MOTIF: serine residue (SEVERAL)
ankyrin repeat
NAME: ankyrin repeat
SITE: 427-459
ankyrin repeat
NAME: ankyrin repeat
SITE: 460-492
ankyrin repeat
NAME: ankyrin repeat
SITE: 493-525
BRCA1 C-terminal (BRCT) motif
SITE: 560-653
BRCA1 C-terminal (BRCT) motif
SITE: 667-777
BRCA1-A complex subunit BRE
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S2}
UEV-like 1 {30-147}
UEV-like 2 {275-364}
Lys-63-specific deubiquitinase BRCC36
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
peptide motif {122-135}
MOTIF: Zn+2-binding site
SITE: 122-122
Zn+2-binding site
SITE: 124-124
Zn+2-binding site
SITE: 135-135
References
- Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS,
Godwin AK, Shiekhattar R.
Regulation of BRCC, a holoenzyme complex containing BRCA1 and
BRCA2, by a signalosome-like subunit and its role in DNA repair.
Mol Cell. 2003 Nov;12(5):1087-99.
PMID: 14636569
- UniProt :accession Q9NXR7
- UniProt :accession P46736
Components
BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; brain & reproductive organ-expressed protein (BRE, BRCC45)
BRCA1-associated RING domain protein 1 (BARD1)
breast cancer type 1 susceptibility protein (BRCA1)
breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein, BRCA2, FACD, FANCD1)
DNA repair protein Rad51 homolog
Lys-63-specific deubiquitinase BRCC36; BRCA1-A complex subunit BRCC36; BRISC complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36 (BRCC3, BRCC36, C61A, CXorf53)