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BRCA1 gene mutation

see BRCA1/BRCA2 genotyping Genetics: - autosomal dominant with incomplete penetrance Complications: - cumulative risk for breast cancer by age 80 - 72% in BRCA1 carriers & 69% in BRCA2 carriers - cumulative risk for ovarian cancer by age 80 - 44% in BRCA1 carriers & 17% in BRCA2 carriers [1]

Related

BRCA1 gene mutation positive BRCA1/BRCA2 genotyping breast cancer type 1 susceptibility protein (BRCA1)

General

BRCA gene mutation (BRACAnalysis CDx)

References

  1. Kuchenbaecker KB, Hopper JL, Barnes DR et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA 2017 Jun 20; 317:2402. PMID: 28632866 http://jamanetwork.com/journals/jama/article-abstract/2632503