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brain-derived microtubule-associated protein tau in serum/plasma
Indications:
- may be useful for evaluation of tauopathy
- may be useful for detecting Alzheimer's-related neurodegeneration & differentiating Alzheimer's disease from other neurodegenerative diseases [1]
Clinical significance:
- correlates with microtubule-associated protein tau in CSF
Procedure:
- brain-derived microtubule-associated protein tau differs from peripherally-derived tau that contains an exon 4a insert between exons 4 & 5*
- an antibody that binds to an expressed glutathione-S-transferase-protein-linked protein construct for the MAPT gene exons 4-5 & of tau recombinant full length tau-441 was developed
- the resulting TauJ.5H3 monoclonal antibody demonstrates specific reactivity to the junction between MAPT exons 4 & 5, excluding tau of peripheral origin with an exon 4a insert
- levels of brain-derived microtubule-associated protein tau in serum/plasma using the TauJ.5H3 monoclonal correlate microtubule-associated protein tau in CSF [1]
Related
microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau)
General
microtubule-associated protein tau in serum/plasma
References
- George J
Novel Blood Test Detects Alzheimer's Neurodegeneration.
Brain-derived tau distinguished Alzheimer's from other dementias.
MedPage Today December 30, 2022
https://www.medpagetoday.com/neurology/alzheimersdisease/102459
- Gonzales-Ortiz F, Turton M, Kac PR et al
Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-
type neurodegeneration.
Brain. 2022. Dec 27.
PMID: 36572122
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac407/6960988