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brain biopsy
Indications:
- brain neoplasms (most common)
- rapidly progressive disease (without brain mass)*
- Creutzfeldt-Jakob disease
- vasculitis
- encephalitis
- lymphoma
- amyloidosis
- demyelination
* not 'true'indications
Clinical significance:
- established a diagnosis in ~36% of cases [1]
- in ~4% if cases, biopsy results changed management
- only lymphoma patients benefitted from change in management
General
tissue biopsy
neurosurgery
References
- Schuette AJ et al.
Open biopsy in patients with acute progressive neurologic
decline and absence of mass lesion.
Neurology 2010 Aug 3; 75:419.
PMID: 20679635