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B-raf1 proto-oncogene or B-raf proto-oncogene

Point mutations in B-raf gene occur in 66% of patients with melanoma [2]. These are somatic (acquired mutations). V599E found in 80% of B-raf point mutations.

Related

serine/threonine protein kinase B-raf; proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1 (BRAF BRAF1 RAFB1)

General

raf proto-oncogene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: serine/threonine protein kinase B-raf LOCUS: 7-CHROMOSOME :ARM q arm (long arm) :SECTION 3 :SUBSECTION 4 MOTIF: transcription factor binding site transcriptional start site exon intron transcriptional termination site

Database Correlations

OMIM 164757 MORBIDMAP 164757

References

  1. OMIM :accession 164757
  2. Journal Watch 22(16):128, 2002 Davies H et al, Nature 417:949, 2002 Pollock PM & Meltzer PS, Nature 417:906, 2002