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bovine spongiform encephalopathy; mad cow disease; BSE

Comparative biology: - prion disease of cattle which has resulted in transmission to 100 young adults in Great Brittain & Europe - the disease in humans is variant Creutzfeldt-Jakob disease (vCJD) - in cattle with mad cow disease, tissues other than CNS shown to be infectious: a) retina b) trigeminal & paraspinal ganglia c) distal ileum d) bone marrow (possibly) [3]

Related

Creutzfeldt-Jakob [CJ] disease prion

General

animal spongiform encephalopathy

References

  1. Journal Watch 21(18):147, 2001
  2. Korth C et al Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci USA 98:9836, 2001 PMID: 11504948
  3. Brown P. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. BMJ 322:841-4, 2001 PMID: 11290640
  4. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
  5. National Institute of Environmental Health Sciences (NIEHS) http://www.niehs.nih.gov/external/faq/madcow.htm