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Borrelia miyamotoi
first identified as a human pathogen in 2011 [2]
Epidemiology:
- now found in Lyme disease vectors worldwide
- transmitted by the Ixodes scapularis tick in northeastern United States
Pathology:
- meningoencephalitis
- found in CSF of older immunocompromised patient with progressive cognitive impairment
- hepatitis
- immunodeficiency/pregnancy may be risk factor
Clinical manifestations:
- rash (faint, lacy erythema, erythema migrans-like [2]
- headache
- fever
Laboratory:
- complete blood count
- thrombocytopenia, leukopenia [2]
- liver function tests
- elevated serum transaminases [2]
- Borrelia miyamotoi serology
- Borrelia burgdorferi serology may be positive
Differential diagnosis:
- anaplasmosis
- borreliosis due to Borrelia burgdorferi Managemeent:
- ceftriaxone plus doxycycline (rifampin in pregnancy)
General
Borrelia
Properties
KINGDOM: monera
DIVISION: SCHIZOMYCETES
References
- Journal Watch
Massachusetts Medical Society
Gugliotta JL et al.
Meningoencephalitis from Borrelia miyamotoi in an
immunocompromised patient.
N Engl J Med 2013 Jan 17; 368:240.
PMID: 23323900
- Hu LT, Tsibris AM, Branda JA.
CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL.
Case 24-2015. A 28-Year-Old Pregnant Woman with Fever,
Chills, Headache, and Fatigue.
N Engl J Med. 2015 Jul 30;373(5):468-75.
PMID: 26222563