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BODE index & prognosis for COPD

Prognostic index for COPD patients. B body mass index O airflow obstruction D dyspnea E exercise capacity Derived from factors strongly associated with 1 year mortality 1) lower body mass index 2) lower FEV1 (airflow obstruction) (< 30% of predicted) [2] 3) higher scores on a dyspnea scale - oxygen dependency [2] 4) shorter distance walked in 6 minutes (exercise capacity) 10 point scale: 0 (lowest risk) - 10 (highest risk) Validation of index: 625 patients with COPD 52 month mortality - 20% with scores 0-2 - 30% with scores 3-4 - 40% with scores 5-6 - 80% with scores 7-10 Predictors of mortality [2] - FEV1 < 30% of predicted - oxygen dependence - multiple hospitalizations for COPD exacerbation - significant comorbidities - weight loss & cachexia - diminished functional status - increasing dependence on others

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chronic obstructive pulmonary disease (COPD)

References

  1. Journal Watch 24(7):55-56, 2004 - Celli BR et al The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 350:1005, 2004 PMID: 14999112
  2. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015