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BCL2/adenovirus E1B 19 kD protein-interacting protein 3 (BNIP3, NIP3)
Function:
1) apoptosis-inducing protein
2) can overcome BCL2 suppression
3) repartitioning Ca+2 between 2 major intracellular Ca+2 stores* in association with BCL2
4) binds to BCL2, adenovirus E1B 19 kD protein
5) interacts with BNIP3L, Epstein-Barr virus BHRF1
* 2 major intracellular Ca+2 stores* = mitochondria, endoplasmic reticulum
Compartment:
- mitochondria, nuclear membrane
- coexpression with the EIB 19-kD protein results in a shift in BNIP3 localization pattern to the nuclear envelope
Related
adenovirus oncoprotein E1b
B-cell leukemia-2 (bcl-2) protein
General
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: MW = 22 kD
entity length = 194 aa
COMPARTMENT: mitochondria
nuclear membrane
MOTIF: transmembrane domain {164-184}
Database Correlations
OMIM 603293
UniProt Q12983
Pfam PF06553
References
UniProt :accession Q12983