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bone morphogenetic protein 2; BMP-2; bone morphogenetic protein 2A; BMP-2A (BMP2, BMP2A)
Function:
- induces cartilage & bone formation
- interacts with SOSTDC1, GREM2, RGMA, RGMB, RGMC & ASPN
Structure:
- homodimer, disulfide-linked
- belongs to the TGF-beta family
Expression:
- expressed in lung, spleen colon > heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary, small intestine
Pharmacology:
- available under the name Infuse (Medtronic Sofamor Danek)
- used for treating open tibial shaft fractures
Specific
recombinant bone morphogenic protein-2 (rhBMP)
General
bone morphogenetic protein (BMP)
TGF-beta family protein
Properties
SIZE: entity length = 396 aa
MW = 45 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
N-glycosylation site {N135}
N-glycosylation site {N163}
N-glycosylation site {N164}
N-glycosylation site {N200}
cysteine residue {C296}
MODIFICATION: cysteine residue {C361}
cysteine residue {C325}
MODIFICATION: cysteine residue {C393}
cysteine residue {C329}
MODIFICATION: cysteine residue {C395}
cysteine residue {C360}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C361}
MODIFICATION: cysteine residue {C296}
cysteine residue {C393}
MODIFICATION: cysteine residue {C325}
cysteine residue {C395}
MODIFICATION: cysteine residue {C329}
Database Correlations
OMIM 112261
UniProt P12643
PFAM correlations
Entrez Gene 650
Kegg hsa:650
References
- UniProt :accession P12643
- Wikipedia; Bone morphogenetic protein 2 entry
http://en.wikipedia.org/wiki/bone_morphogenetic_protein_2