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bisphosphoglycerate mutase (BPGM)
Function:
- major role in regulating hemoglobin oxygen affinity as a consequence of controlling 2,3-DPG concentration
- has mutase & phosphatase activities, albeit diminished
3-phospho-D-glyceroyl phosphate 2,3-bisphospho-D-glycerate
2-phospho-D-glycerate 3-phospho-D-glycerate
2,3-bisphospho-D-glycerate + H2O
3-phospho-D-glycerate + phosphate
Structure:
- homodimer
- belongs to the phosphoglycerate mutase family, BPG- dependent PGAM subfamily
Pathology:
- glycation of Lys-159 in hyperglycemic diabetic patients inactivates the enzyme
Related
2,3-diphosphoglycerate (2,3-DPG); 2,3-bisphosphoglycerate (2,3-BPG)
General
mutase
oligomerizing protein
phosphomonoesterase
phosphotransferase
Properties
SIZE: entity length = 259 aa
MW = 30 kD
MOTIF: histidine residue {H11}
lysine residue {29}
lysine residue {46}
arginine residue {62}
lysine residue {143}
lysine residue {181}
histidine residue {H188}
lysine residue {246}
lysine residue {247}
lysine residue {253}
lysine residue {258}
lysine residue {259}
Database Correlations
OMIM 222800
UniProt P07738
Pfam PF00300
KEGG correlations
ENZYME 5.4.2.4
References
UniProt :accession P07738