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bisphenol A (BPA)

Uses: - used in the production of polycarbonate plastics & epoxy resins that are commonly found in some baby bottles, water containers, linings of metal food cans, etc Contraindications: - FDA bans use in baby bottles & cups [7] Pathology: - report that people with higher urine levels of BPA are more likely to have diabetes & heart disease - no association between urinary BPA level & type 2 diabetes [3] - prenatal exposure to bisphenol A is associated with neurobehavioral problems in girls (but not boys) at age 3 years [4] - enough evidence to ban BPA in food containers [6] - association with increased urinary BPA & obesity in children & adolescents [8] - high serum levels of bisphenol A in the first trimester of pregnancy is associated with increased risk of miscarriage [9] - exposure increases risk of early-onset prostate cancer [11] - higher urine levels of BPA are associated with increased risk of hypertension in the elderly [12] Clinical trials: 1) 75 adults ate 12 oz of fresh vs canned soup for 5 days, then crossed over to the other soup for another 5 days [5] - urine bisphenol A, collected on days 4 & 5 for each phase was detected in: - 77% fresh soup - 100% canned soup - average urine bisphenol A concentration was ~23 ug/L higher after canned vs fresh soup [5] - comment: a control group that did not eat soup at all would have been nice 2) handling of thermal-activated receipt paper without gloves increases bisphenol A levels in urine [10] 3) urinary BPA concentrations were higher 2 hours after elderly subjects drank soy milk from 2 cans versus 2 glass bottles - systolic BP was ~4.5 mm Hg higher after 2 cans versus 2 glass bottles [12] * cohort studies or case-control studies needed to investigate clinical outcomes of bisphenol A exposure Notes: - how to identify polycarbonate plastics; these usually have the number 7 in the recycling triangle, but 7 is a catch-all category...and not all 7s are polycarbonate

General

phenol

Database Correlations

PUBCHEM cid=6623

References

  1. Prescriber's Letter 15(11): 2008 Health Risks of Bisphenol A Detail-Document#: 241108 (subscription needed) http://www.prescribersletter.com
  2. Lang IA et al Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 2008 Sep 17;300(11):1303-10. Epub 2008 Sep 16. PMID: 18799442
  3. Ning G et al. Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: A cross-sectional analysis. Ann Intern Med 2011 Sep 20; 155:368 PMID: 21930854
  4. Braun JM et al Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children Pediatrics October 24, 2011 http://pediatrics.aappublications.org/content/early/2011/10/20/peds.2011-1335.abstract
  5. Carwile JL et al Canned Soup Consumption and Urinary Bisphenol A: A Randomized Crossover Trial JAMA. 2011;306(20):2218-2220
  6. Massachusetts Medical Society, Physician's First Watch April 2, 2012 FDA rejects BPA Ban http://www.jwatch.org
  7. Physician's First Watch Massachusetts Medical Society, July 30, 2012 - Tavernise S FDA Makes it Official: BPA cannot be used in Baby Bottles and Cups New York Times, July 17, 2012 http://www.nytimes.com/2012/07/18/science/fda-bans-bpa-from-baby-bottles-and-sippy-cups.html?_r=1
  8. Trasande L et al Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents. JAMA. 2012;308(11):1113-1121 PMID: 22990270 http://jama.jamanetwork.com/article.aspx?articleid=1360865
  9. Physician's First Watch, October 15, 2013 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  10. Ehrlich S et al Handling of Thermal Receipts as a Source of Exposure to Bisphenol A. JAMA. 2014;311(8):859-860. PMID: 24570250 https://jama.jamanetwork.com/article.aspx?articleid=1832525
  11. Tarapore P et al Exposure to Bisphenol A Correlates with Early-Onset Prostate Cancer and Promotes Centrosome Amplification and Anchorage- Independent Growth In Vitro. PLOS One. March 03, 2014 PMID: 24594937 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090332
  12. Orciari Herman A, Fairchild DG, Hefner JE BPA in Canned Beverages Linked to Increases in Blood Pressure Physician's First Watch, Dec 9, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Bae S et al Blood Pressure and Aging. Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure. Hypertension. 2012; 60: 786-793 PMID: 22851732 http://hyper.ahajournals.org/content/60/3/786.full