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BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1 (BAG3, BIS)
Function:
- inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release
- has anti-apoptotic activity
- binds to the ATPase domain of HSP70/HSC chaperones
- binds to Bcl-2 & PLC-gamma
Structure:
- contains 1 BAG domain
- contains 2 WW domains
General
bcl-2 binding athanogene (bag) protein
docking protein
Properties
SIZE: entity length = 575 aa
MW = 62 kD
MOTIF: WW domain (W/rsp5/WWP domain) {20-54}
WW domain (W/rsp5/WWP domain) {124-154}
MOTIF: Ser phosphorylation site {S134}
Ser phosphorylation site {S136}
Ser phosphorylation site {S171}
Ser phosphorylation site {S173}
serine-rich region {180-187}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S194}
Tyr phosphorylation site {Y240}
Tyr phosphorylation site {Y247}
Ser phosphorylation site {S274}
Ser phosphorylation site {S275}
Ser phosphorylation site {S279}
Thr phosphorylation site {T285}
Ser phosphorylation site {S289}
Ser phosphorylation site {S291}
Ser phosphorylation site {S377}
Ser phosphorylation site {S385}
Ser phosphorylation site {S386}
Thr phosphorylation site {T406}
BAG {421-498}
Database Correlations
OMIM 603883
MORBIDMAP 603883
UniProt O95817
PFAM correlations
Entrez Gene 9531
Kegg hsa:9531
References
- UniProt :accession O95817
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/BAG3ID43160ch10q26.html
- Entrez Gene :accession 9531