baculoviral IAP repeat-containing protein 5 selections

baculoviral IAP repeat-containing protein 5; apoptosis inhibitor survivin; apoptosis inhibitor 4 (BIRC5, API4, IAP4)

Function: - peptide inhibitor of apoptosis - may counteract a default induction of apoptosis in G2/M phase - interacts with tubulin inhibitor of caspase-3 & caspase-7 - component of the chromosomal passenger complex - isoforms 2 & 3 do not appear to play vital roles in mitosis - isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform - when phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently - interacts with EVI5 Structure: - homodimer - the BIR repeat is necessary & sufficient for HBXIP binding - belongs to the IAP family - contains 1 BIR repeat Compartment: - cytoplasm, nucleus, centromere - localizes on chromosome arms & inner centromeres from prophase through metaphase & then transferring to the spindle midzone & midbody from anaphase through cytokinesis - colocalizes with AURKB at mitotic chromosomes Alternative splicing: named isoforms=7 Expression: - expressed only in fetal kidney & liver, & to lesser extent, lung & brain Pathology: - BIRC5 may play a role in neoplasia - identified in several human cancers - overproduction may foster survival of neoplastic cells otherwise programmed or targeted for apoptosis - abundantly expressed in adenocarcinomas a) lung adenocarcinoma b) pancreatic carcinoma c) colorectal carcinoma d) breast carcinoma e) prostate carcinoma - also abundantly expressed in high-grade lymphomas - also expressed in various renal cell carcinoma cell lines Laboratory: - urinary survivin (or survivin mRNA) measurements may be useful for identifying new-onset or recurrent bladder cancer

General

inhibitor of apoptosis protein; baculoviral IAP repeat containing protein; BIRC protein (IAP; BIRC) phosphoprotein

Properties

SIZE: entity length = 142 aa MW = 16 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: BIR {18-88} MOTIF: Thr phosphorylation site {T34} Zn+2-binding site SITE: 57-57 Zn+2-binding site SITE: 60-60 Zn+2-binding site SITE: 77-77 Zn+2-binding site SITE: 84-84

Database Correlations

OMIM 603352 UniProt O15392 Pfam PF00653 Entrez Gene 332 KEGG correlations

References

Ambrosini G et al A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nature Medicine 3:917-21 1997 PMID: 9256286
Journal Watch 21(5):42, 2001 Simith et al JAMA 285:324, 2001
Entrez Gene :accession 332
UniProt :accession O15392
NIEHS-SNPs http://egp.gs.washington.edu/data/birc5/

Component-of

chromosome passenger complex