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baculoviral IAP repeat-containing protein 3; inhibitor of apoptosis protein 1; HIAP-1; HIAP1; C-IAP2; TNFR2-TRAF-signaling complex protein 1; IAP homolog C; apoptosis inhibitor 2; API2; RING finger protein 49 (BIRC3, API2, IAP1, MIHC, RNF49)
Function:
- apoptotic suppressor
- the N-terminal BIR domain interacts with TNF receptor associated factors 1 & 2 (TRAF1 & TRAF2) to form a heteromeric complex, which is then recruited to TNF receptor 2 (TNFR2)
- interacts with SMAC & with PRSS25; these interactions inhibit apoptotic suppressor activity
Structure:
- belongs to the IAP family
- contains 3 BIR repeats
- contains 1 CARD domain
- contains 1 RING-type Zn+2 finger
Compartment: cytoplasm (putative)
Expression:
- highly expressed in fetal lung, & kidney
- in adult, expression is mainly seen in lymphoid tissues, including spleen, thymus & peripheral blood lymphocytes
Pathology:
- chromosomal translocation t(11;18)(q21;q21) involving BIRC3 with MALT1 is recurrent in low-grade MALT lymphoma
General
inhibitor of apoptosis protein; baculoviral IAP repeat containing protein; BIRC protein (IAP; BIRC)
ring finger protein
Properties
SIZE: entity length = 604 aa
MW = 68 kD
COMPARTMENT: cytoplasm
MOTIF: BIR {29-96}
BIR {169-235}
BIR {255-322}
MOTIF: Zn+2-binding site
SITE: 292-292
Zn+2-binding site
SITE: 295-295
Zn+2-binding site
SITE: 312-312
Zn+2-binding site
SITE: 319-319
CARD domain {439-529}
MOTIF: breakpoint {442-443}
RING-finger {557-592}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM 601721
UniProt Q13489
PFAM correlations
Entrez Gene 330
KEGG correlations
References
- Entrez Gene :accession 330
- UniProt :accession Q13489
Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/BIRC3ID239.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/birc3/