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bipolar I disorder

Clinical manifestations: - at least one manic episode - a single manic episode is sufficient for diagnosis if other causes are ruled out - depressive episodes are common but not required for diagnosis - some patients never have a depressive episode Laboratory: - urine drug screen - amphetamines in urine - cocaine in urine - benzoylecgonine in urine Management: - see bipolar disorder - adjunctive antidepressants may be stopped after remission of depression [2]

General

bipolar affective disorder

References

  1. NEJM Knowledge+ Question of the Week. Aug 15, 2017 https://knowledgeplus.nejm.org/question-of-week/1288/
  2. Yatham LN, Arumugham SS, Kesavan M et al. Duration of adjunctive antidepressant maintenance in bipolar I depression. N Engl J Med 2023 Aug 3; 389:430. PMID: 37530824 https://www.nejm.org/doi/10.1056/NEJMoa2300184