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Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death (BCL2L11, BIM)

Function: - induces apoptosis - isoform BimL is more potent than isoform BimEL - isoform Bim-alpha1, isoform Bim-alpha2 & isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL & BimS - isoform Bim-gamma induces apoptosis - heterodimerizes with antiapoptotic bcl-2 family protein members: MCL-1, BCL-2, BCL-XL, BFL-1, & BHRF-1; does not heterodimerize with proapoptotic members BAD, BOK, BAX or BAK (putative) - required for apoptosis of autoreactive thymocytes [2] Structure: - one of the 'BH3 domain only' members of the bcl-2 family of proteins - the BH3 motif is required for Bcl-2 binding & cytotoxicity Compartment: - intracytoplasmic membrane; peripheral membrane protein (putative - associated with intracytoplasmic membranes (putative) - isoform BimEL: mitochondrion - isoform BimL: mitochondrion - isoform BimS: mitochondrion - isoform Bim-alpha1: mitochondrion Alternative splicing: named isoforms=17; BimEL, BimL, BimS, Bim-alpha, Bim-beta, Bim-gamma forms Expression: - isoform BimEL, isoform BimL & isoform BimS are the predominant isoforms & are ubiquitously expressed with a tissue-specific variation - isoform Bim-gamma is most abundantly expressed in small intestine & colon, & in lower levels in spleen, prostate, testis, heart, liver & kidney

Interactions

molecular events

General

BH3 subfamily protein pro apoptotic protein

Properties

SIZE: entity length = 198 aa MW = 22 kD COMPARTMENT: mitochondria cytoplasm MOTIF: Ser phosphorylation site {S77} BH3 domain NAME: BH3 domain SITE: 148-162

Database Correlations

OMIM 603827 UniProt O43521 PFAM correlations Entrez Gene 10018 KEGG correlations

References

  1. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: 11165519
  2. Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H, Pellegrini M, Cory S, Adams JM, Strasser A. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature. 2002 Feb 21;415(6874):922-6. Erratum in: Nature 2002 Jul 4;618(6893):108. PMID: 11859372
  3. UniProt :accession O43521
  4. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/BCL2L11ID772ch2q13.html

Component-of

molecular complex