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biliverdin reductase

Function: - reduces bilirubin to biliverdin in the catabolism of heme & in the biliverdin reductase cycle, a key antioxidant system in the central nervous system. [2] - electrons donated by NADPH. biliverdin reductase biliverdin ------------------> bilirubin + NADP+ + NADPH + H+

Interactions

molecular events

Related

biliverdin reductase cycle heme catabolism

Specific

biliverdin reductase A, adult (BLVRA, biliverdin IX-alpha reductase) biliverdin reductase B, fetal (BLVRB, biliverdin IX beta-reductase, NADPH-flavin reductase, FLR, BVR-B, biliverdin-IX beta-reductase, green heme-binding protein, GHBP, BLVRB, FLR)

General

oxidoreductase

Properties

COMPARTMENT: smooth endoplasmic reticulum MOTIF: cofactor-binding site COFACTOR-BOUND: NADH NADPH

Database Correlations

OMIM 109750 ENZYME 1.3.1.24

References

  1. OMIM :accession 109750
  2. Sedlak TW, Snyder SH. Messenger molecules and cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: 16391220