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bile salt-activated lipase; BAL; bile salt-stimulated lipase; BSSL; carboxyl ester lipase; sterol esterase; cholesterol esterase; pancreatic lysophospholipase (CEL)
Function:
- catalyzes fat & vitamin absorption
- acts in concert with pancreatic lipase & colipase for the complete digestion of dietary triglycerides
- activated by bile salts containing a 7-hydroxyl group
triacylglycerol + H2O diacylglycerol + carboxylate
steryl ester + H2O sterol + fatty acid
Structure: belongs to the type-B carboxylesterase/lipase family
Alternative splicing: named isoforms=2
Expression: mammary gland & pancreas
Pathology:
- defects in CEL are a cause of mature-onset diabetes of the young type 8 with exocrine dysfunction (MODY8)
General
lysophospholipase
Properties
SIZE: entity length = 742 aa
MW = 78 kD
COMPARTMENT: extracellular compartment
WITHIN: intestine
MOTIF: signal sequence {1-20}
binding site
SITE: 21-121
FOR-BINDING-OF: heparin
MOTIF: cysteine residue {C84}
MODIFICATION: cysteine residue {C100}
cysteine residue {C100}
MODIFICATION: cysteine residue {C84}
N-glycosylation site {N207}
serine residue {S214}
cysteine residue {C266}
MODIFICATION: cysteine residue {C277}
cysteine residue {C277}
MODIFICATION: cysteine residue {C266}
aspartate residue {D340}
histidine residue {H455}
Thr glycosylation site {T558}
16 X 11 AA tandem repeats, glycodomain, O-linked (mucin type) {559-734}
MOTIF: consensus repeat {559-569}
Thr glycosylation site {T569}
consensus repeat {570-580}
Thr glycosylation site {T579}
consensus repeat {581-591}
consensus repeat {592-602}
Thr glycosylation site {T596}
consensus repeat {603-613}
Thr glycosylation site {T607}
consensus repeat {614-624}
Thr glycosylation site {T618}
consensus repeat {625-635}
Thr glycosylation site {T629}
consensus repeat {636-646}
Thr glycosylation site {T640}
consensus repeat {647-657}
Thr glycosylation site {T651}
consensus repeat {658-668}
Thr glycosylation site {T662}
consensus repeat {669-679}
Database Correlations
OMIM correlations
UniProt P19835
Pfam PF00135
KEGG correlations
ENZYME correlations
References
UniProt :accession P19835