Contents

Search

bilateral salpingo-oophorectory (BSO)

Surgical removal of fallopian tubes & ovaries, generally in association with total abdominal hysterectomy. Indications: - bilateral - ovarian cancer - fallopian tube cancer - prophylactic bilateral salpingo-oophorectomy (BSO), with or without hysterectomy, after completion of childbearing is the standard of care for female carriers of BRCA1 mutation or BRCA2 mutation [1] Complications: - bilateral salpingo-oophorectomy before menopause may lead to medial temporal lobe neurodegeneration & early dementia [4] Management: - in premenopausal women, hormone replacement therapy may mitigate menopausal symptoms & excess risk for osteoporosis [3]

Specific

total abdominal hysterectomy, bilateral salpingo-oophorectory (TAH-BSO)

General

salpingo-oophorectory

References

  1. Rebbeck TR et al. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. J Natl Cancer Inst 2009 Jan 21; 101:80. PMID: 19141781 - Greene MH and Mai PL. What have we learned from risk-reducing salpingo-oophorectomy? J Natl Cancer Inst 2009 Jan 21; 101:70. PMID: 19141782
  2. Ward SM, Chelmow D Medscape: Salpingo-Oophorectomy http://emedicine.medscape.com/article/1894587-overview
  3. Shu CA et al Uterine cancer after risk-reducing salpingo-oophorectomy without hysterectomy in women with BRCA mutations. JAMA Oncol 2016 Jun 30 PMID: 27367496 http://oncology.jamanetwork.com/article.aspx?articleid=2531470 - Leath CA et al. Drawing the line in risk-reducing gynecologic surgery in women with a BRCA mutation. JAMA Oncol 2016 Jun 30 PMID: 27367041 http://oncology.jamanetwork.com/article.aspx?articleid=2531467
  4. Zeydan B et al. Association of bilateral salpingo-oophorectomy before menopause onset with medial temporal lobe neurodegeneration. JAMA Neurol 2018 Oct 15 https://www.jwatch.org/na47763/2018/10/29/protect-brain-look-ovaries