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Bicillin CR
Combination of 1st generation penicillins.
Combination of procaine penicillin & benzathine penicillin
Indications:
1) for IM use in mixes of 150/150, 300/300, 600/600, 300/900 (procaine/benzathine penicillin)
2) active against most gram positive organisms, especially Streptococcus species
Contraindications:
pregnancy-category B
safety in lactation ?
Dosage:
1) children > 60 lbs & adults:
- 2.4 million units IM (single dose)
2) children 30-60 lbs:
- 1.2 million units IM (single dose)
3) children < 30 lbs:
- 600,000 units IM (single dose)
Pharmacokinetics: elimination: kidney
Adverse effects:
- not common (1-10%)
1) Jarisch-Herxheimer reaction
2) CNS toxicity
a) convulsions
b) confusion
c) drowsiness
d) myoclonus
3) positive direct antiglobulin (Coomb's) test (DAT)
4) hemolytic anemia
5) interstitial nephritis
6) hypersensitivity
General
antibiotic combination
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
benzathine penicillin (Bicillin L-A)
procaine penicillin (Wycillin)