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bcl-2 homology 3 (BH3) domain

A death domain characteristic of pro-apoptotic bcl-2 family members. It is an amphipathic alpha helical sequence & a binding site for ligand interactions.

General

bcl-2 homology (BH) domain binding site

Properties

NAME: BH3 domain

References

  1. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: 11165519