biglycan; bone/cartilage proteoglycan I; PG-S1 (BGN, SLRR1A)

Function: - may be involved in collagen fiber assembly - the two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (putative) - forms a ternary complex with MFAP2 & ELN Structure: - homodimer - belongs to the small leucine-rich proteoglycan (SLRP) family, class I subfamily - contains 12 LRR repeats (leucine-rich repeats) Compartment: - secreted, extracellular space, extracellular matrix (putative) Expression: - found in several connective tissues, especially in articular cartilages

General

matrix protein proteoglycan core protein

Properties

SIZE: entity length = 368 aa MW = 42 kD COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-19} Ser glycosylation site {S42} Ser glycosylation site {S47} cysteine-rich region {63-76} MOTIF: cysteine residue {C63} MODIFICATION: cysteine residue {C69} cysteine residue {C67} MODIFICATION: cysteine residue {C76} cysteine residue {C69} MODIFICATION: cysteine residue {C63} cysteine residue {C76} MODIFICATION: cysteine residue {C67} leucine-rich repeat SITE: 82-102 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 103-126 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 127-150 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 151-171 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 172-195 MOTIF: leucine residue (SEVERAL) Ser glycosylation site {S180} leucine-rich repeat SITE: 196-220 MOTIF: leucine residue (SEVERAL) Ser glycosylation site {S198} leucine-rich repeat SITE: 221-241 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 242-265 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 266-289 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N270} leucine-rich repeat SITE: 290-312 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N311} leucine-rich repeat SITE: 313-342 MOTIF: leucine residue (SEVERAL) cysteine residue {C321} MODIFICATION: cysteine residue {C354} leucine-rich repeat SITE: 343-368 MOTIF: leucine residue (SEVERAL) cysteine residue {C354} MODIFICATION: cysteine residue {C321}

Database Correlations

OMIM 301870 UniProt P21810 PFAM correlations Entrez Gene 633 Kegg hsa:633