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betaxolol (Kerlone, Betoptic)

Tradenames: Kerlone, Betoptic. Indications: 1) glaucoma a) open-angle glaucoma b) secondary glaucoma c) increased intraocular pressure 2) systemic beta-blocker - hypertension Cautions: 1) bronchial asthma 2) sinus bradycardia 3) 2nd & 3rd degree AV block 4) heart failure Dosage: 1) ophthalmic: 1 drop OU BID 2) systemic: - start 10 mg PO QD - may iincrease to 20 mg/day Solution: 0.25%, 0.5%. Tabs: 10 & 20 mg. Adverse effects: 1) ocular - ocular stinging, photophobia, keratitis, tearing, erythema, itching, decreased corneal sensitivity 2) systemic effects a) not common (1-10%) - bradycardia, palpitations, edema, congestive heart failure, cold extremities, dizziness, fatigue, lethargy, headache b) uncommon (< 1%) - nervousness, depression, chest pain, thrombocytopenia, hallucinations Mechanism of action: 1) beta-1 adrenergic receptor antagonist; little effect on beta-2 adrenergic receptors 2) reduces production of aqueous humor 3) no effect on accomodation or pupillary size 4) intraocular pressure diminishes by 20-35%

Interactions

drug interactions drug adverse effects (more general classes)

Specific

levobetaxolol (Betaxon)

General

beta-1 adrenergic receptor antagonist (beta-1 blocker)

Properties

MISC-INFO: elimination route LIVER KIDNEY pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Deprecated Reference

Component-of

betaxolol/pilocarpine