betacellulin; probetacellulin (BTC)

Function: - potent mitogen for retinal pigment epithelial cells & vascular smooth muscle cells - effects of betacellulin are probably mediated by the EGF receptor & other related receptors Structure: - monomer - contains 1 EGF-like domain Compartment: - betacellulin: secreted, extracellular space - probetacellulin: cell membrane, single-pass type 1 membrane protein Expression: - synthesized in several tissues & tumor cells - predominantly expressed in pancreas & small intestine Pathology: - betacellulin from beta cells could play a role in the vascular complications associated with diabetes

General

glycoprotein plasma membrane protein

Properties

SIZE: entity length = 178 aa MW = 20 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-31} N-glycosylation site {N34} EGF domain {65-105} MOTIF: cysteine residue {C69} MODIFICATION: cysteine residue {C82} cysteine residue {C77} MODIFICATION: cysteine residue {C93} cysteine residue {C82} MODIFICATION: cysteine residue {C69} cysteine residue {C93} MODIFICATION: cysteine residue {C77} cysteine residue {C95} MODIFICATION: cysteine residue {C104} cysteine residue {C104} MODIFICATION: cysteine residue {C95} transmembrane domain {119-139} lysine-rich region {146-154} MOTIF: lysine residue (SEVERAL)

Database Correlations

OMIM 600345 UniProt P35070 Pfam PF00008 Entrez Gene 685 Kegg hsa:685

References

UniProt :accession P35070