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beta(3)-hydroxybutyrate in blood/plasma/serum

Indications: - useful for following therapy for diabetic ketoacidosis Normal range: 1) 0.21-2.81 mg/dL (20-270 umol/L) [Ketosite, GDS Diagnostics] 2) < 3.02 mg/dL (290 umol/L) [enzymatic method] Clinical significance: - in diabetic ketoacidosis (DKA), beta-hydroxybutyrate is the predominant accumulated intermediary metabolite & is a better indicator of clinical state than acetoacetate. - the beta-hydroxybutyrate/acetoactetate ratio is normally 3:1 & will rise to 6-12:1 during ketoacidosis - beta-hydroxybutyrate is NOT detected by common tests for ketone bodies (Acetest, Chemstrip, Ketostix) Increases: 1) ketoacidosis: diabetic, alcoholic, lactic 2) shock, renal failure 3) liver disease 4) infections 5) phenformin 6) salicylate poisoning Specimen: 1) whole blood, plasma or serum (EDTA, heparin, oxalate, citrate) 2) store in refrigerator for up to 12 hours 3) freeze serum or plasma (Ketosite) 4) do NOT freeze specimen for enzymatic assay

Related

acetoacetate in serum/plasma beta-hydroxybutyrate; 3-hydroxybutyrate ketone bodies in body fluid

Specific

beta(3)-hydroxybutyrate in blood beta(3)-hydroxybutyrate in serum/plasma

General

beta-hydroxybutyrate in body fluid

References

  1. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  2. Beta-Hydroxybutyric Acid Laboratory Test Directory ARUP: 80045
  3. Panel of 10 tests Laboratory Test Directory ARUP: 99289